High Throughput Screening Equipment

High-throughput screening in drug discovery. The primary goal of HTS is to identify through compound library screenings, candidates that affect the target in the desired way, so called “hits” or “leads”. This is usually achieved employing liquid handling devices, robotics, plate readers as detectors and dedicated software for instrumentation control and data processing.

High throughput screening equipment. High-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Equipment. The High-Throughput Screening Facility at the ICGEB is equipped with state-of-the-art instrumentation to perform genome-wide RNA interference screenings and is organized around three major workstations: Liquid handling (Hamilton STARlet) Multimode plate reading (PerkinElmer Envision) what are the costs of a high throughput screening with a chemical compound library? How can I find a HTS facility that also provides a chemical compound library (>10.000) and is willing to perform the screening in collaboration? Is there a way to perform such a (very promising) screen for free and the results are "shared"? Northwestern’s High Throughput Analysis Lab (NU-HTA) has grown over the last decade into a premier open resource for this kind of research. We’re committed to providing Chicago’s life science community an affordable way to set up, run, gather data and perform analysis from tens to tens of thousands of parallel experiments using up-to-date.

Equipment. Besides a typical collection of generalized laboratory equipment (e.g., freezers, refrigerators, CO 2 incubators, etc.), the Quellos HTS Core contains essential instrumentation and equipment that makes high-throughput screening possible: Liquid Handlers: Analytik Jena CyBio CyBi-Well Vario Liquid Handler Equipment & Resources. The High-throughput screening (HTS) system (HighRes Biosolutions) is a fully integrated automated screening system equipped with a Staubli TX90XL robotic arm, a 420-plate random-access carousel for storage of compound and assay plates, a 210-plate STX240 Liconic incubator for cell-based assays, two Velocity 11 VSpin centrifuges, a Perkin Elmer ViewLux multimode CCD based. High-throughput screening solutions from Eurofins Discovery will enable you to identify quality hits that progress to lead candidates. Over 4,500 assays ready to use off-the-shelf allow your screen to be completed in 4-6 weeks. High-throughput screening (HTS) is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests.

ChemDiv has assembled a robust high throughput screening platform encompassing automated liquid handling and multimode signal detection equipment for assays to be ran in up to 1536-well plate formats. Multimode reading capability provides access to screening assays with multiplicity of targets, such as receptors, enzymes, signaling pathways etc. that play a major role in different therapeutics. Robotic Workstations Semi-Automated Liquid-Handling Worstation Biomek FX pipettor with 96-well multi-channel head, 250uL capacity (Beckman Coulter) Up to 22 positions for plates/tip boxes Fully Integrated Assay Workstation Biomek FXP dual Arm system with 96-well multi-channel head, 250uL capacity, a Span-8 head, 250uL/1000uL capacity, and bar codes readers (Beckman Coulter) 384-well magnetic. High throughput cell biology is the use of automation equipment with classical cell biology techniques to address biological questions that are otherwise unattainable using conventional methods. It may incorporate techniques from optics, chemistry, biology or image analysis to permit rapid, highly parallel research into how cells function, interact with each other and how pathogens exploit. The high-throughput screening facility in the School of Chemical Sciences at the University of Illinois at Urbana-Champaign (UIUC) was created to assist researchers in developing and performing high-throughput screens of chemical libraries.. The HTSF provides the equipment resources that your laboratory personnel can use to develop assays or.

High-throughput Screening Facility Equipment: Liquid Handlers- PlateMate Plus and WellMate. Plate Readers - Analyst HT and Cytation 5. Chemspeed SLTII. Plate Washer & Plate Sealer. Centrifuge. Cell culture hood and incubators Charles River offers HTMS on high-capacity equipment, paired with the added flexibility of column chromatography. By examining chemical motifs and scaffolds found to have activity in the primary high- throughput screen, we can mine our extensive compound collection and select sets of related compounds for follow-on screening. Category: High Throughput Screening Managed by: NDM- Target Discovery Institute, University of Oxford: Description: The HTS facility provides Oxford research scientists and collaborators access to a comprehensive, cost-effective facility for running high throughput cell based small compound and RNAi screens across a broad range of readouts. M.S. Attene-Ramos,. M. Xia, in Encyclopedia of Toxicology (Third Edition), 2014. Definition. High throughput screening (HTS) is the use of automated equipment to rapidly test thousands to millions of samples for biological activity at the model organism, cellular, pathway, or molecular level. In its most common form, HTS is an experimental process in which 10 3 –10 6 small molecule.

The protocol described in this paper can be easily adapted to utilize different plate densities (1536-, 384- or 96-wells) and diverse liquid handling and screening equipment. In a low throughput mode, the assay could be performed using 8- or 12-channel pipettes. For high throughput screening specialized liquid handling equipment is required. The ACTD Facility is comprised of two main screening workstations, the High-Throughput Workstation, and the High-Content Workstation. These workstations are operated independently of each other, are fully automated, and are equipped with various screening equipment, depending on the specific assay requirements. High-throughput Screening Main content NEXUS specializes in assay development, high-throughput screening and data analysis and gives you access to high-end lab automation equipment, unique state-of-the-art small-molecule libraries, as well as gene manipulation tools such as shRNA libraries. 1. Basics of Assay Equipment and Instrumentation for High Throughput Screening. Jones E, Michael S, Sittampalam GS. In: Sittampalam GS, Coussens NP, Nelson H, Arkin M.

The High-Throughput Screening Core Facility makes it possible to carry out a variety of biochemical and cell-based assays. It offers great versatility in the type of assays that can be developed as well as their miniaturization and automation.